Conjugation of some NSAIDs with 5-phenyl-2-aminothiazole for reduced ulcerogenicity

Abstract

Analgesic drugs containing free acidic group were reacted with N, N' carbonyldiimidazole to prepare the acylimidazole derivatives. They were further reacted with 5-phenyl-2-amino thiazole nucleus to obtain the corresponding amides. All the compounds were found to retain analgesic-antiinflammatory activities with much lesser NSAID-induced GI complications when compared with the standard.