Transformation of Santonin to a Naproxen Analogue with Anti-Inflammatory Activity

dc.contributor.author	Singh R.; Mandrah K.; Asati A.; Patel D.K.; Goel B.; Vishwakarma R.A.; Roy S.K.; Jain S.K.
dc.date.accessioned	2025-05-24T09:40:08Z
dc.description.abstract	Santonin, a natural product, was aromatized with molecular iodine as the catalyst. The new compound was characterized as (S)-methyl-2-(7-hydroxy-5,8-dimethylnaphthalen-2-yl) propanoate (2) based on 2D NMR spectroscopic data. Structurally, compound 2 was highly similar to the anti-inflammatory drug naproxen. The new naproxen analogue had significant potency against cyclooxygenase 1 and 2 (IC50 = 31.0 and 66.1 μM, respectively). © 2019 American Chemical Society and American Society of Pharmacognosy.
dc.identifier.doi	https://doi.org/10.1021/acs.jnatprod.8b00318
dc.identifier.uri	http://172.23.0.11:4000/handle/123456789/18895
dc.relation.ispartofseries	Journal of Natural Products
dc.title	Transformation of Santonin to a Naproxen Analogue with Anti-Inflammatory Activity

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