Transdermal delivery of propranolol

Abstract

Three transdermal formulations containing propranolol hydrochloride in a hydrophilic polymer matrix were prepared-one without a rate controlling membrane(H-1), one with a 20μ thick Ethylene Vinyl Acetate(EVA) rate controlling membrane (H-2) and one with a 65μ thick EVA membrane. These patches were evaluated for their in-vitro performance. Cumulative % permeated across excised hairfree rat skin were 79.2% from H-1, 65.53% from H-2 and 53.44% from H-3. Increase in thickness of EVA lead to greater retention of drug in device and a zero order profile was seen with patches H-2 & H-3. Matrix diffusion profile was observed with H-1 patch. © 1994 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.