Studies on the competitive interaction of glutathione with 3-aminopropyltrimethoxysilane-stabilized gold nanoparticles

Abstract

Gold nanoparticles (AuNps) of controlled nanogeometry have been synthesized by 3-Glycidoxypropyltrimethoxysilane (3-GPTMS) mediated reduction of gold chloride in the presence of 3-aminopropyltrimethoxysilane (3-APTMS). It has been found that 3-APTMS control the size of AuNps followed by acting as potential stabilizer for the same. An increase in 3-APTMS concentration resulted into an increase in the size of AuNps. The interaction of Glutathione with 3-APTMS-stabilized AuNps has been investigated. The dynamics of GSH and AuNps has been found as a function of 3-APTMS concentration. Higher concentration of 3-APTMS results into slower kinetics AuNps-GSH interaction followed dramatic variation in the size of AuNps. A comparative study with AuNps functionalized with citrate and polyvinylpyrrolidone was performed. The results based on UV-VIS spectroscopy and impedance analysis are presented.