Antiaggressive activity of Nyctanthes arbor-tristis leaves in rodents

Abstract

Hydroalcoholic extract of leaves of Nyctanthes arbor-tristis Linn (NATE) was pharmacologically validated for its antiagressive properties in experimental animals using various models such as Foot shock-induced aggression, Isolation-induced aggression, Resident-intruder aggression and Water competition test.Extract was given orally at two different dose levels (250 and 500 mg/kg) once daily for three consecutive days, while Diazepam (2.5mg/kg), was administered as positive control.NATE. (250 and 500mg/kg) on all the models produced significant antiagressive effects such as a reduction in vocalizations along with lowering of leaping, running, rearing and facing each other, increased latency time to first attack, reduced spout gaining frequency along with a reduction in time spent which was found to be statistically significant compared to the control. Results suggested that NATE showed significant antiagressive activity.