TiO2-nanowired cerebrolysin attenuated hyperthermia induced ubiquitin overexpression and brain pathology

Abstract

Our military personnel are often engaged in combat operations in desert environments during summer months across the World. In such situations, apart from their exposure to missiles, roadside bomb or other explosive related nanoparticles exposure, they are also exposed to silica dust (SiO2) nanoparticles. Previous experiments from our laboratory showed that SiO2 exposure exacerbates heat stress induced brain pathology. Thus, this is likely that our soldiers that are exposed to SiO2 nanoparticles under heats tress are prone to central nervous system (CNS) dysfunction. Since ubiquitin is present in almost all cells and responsible for intracellular protein degradation, in present innovation we examined ubiquitin expression in heat stress and its modification with SiO2 nanoparticles in a rat model. Our observations show that SiO2 enhances ubiquitin overexpression in heat stress and that could be one of the key mechanisms responsible for brain pathology.