In vitro characterization of non-degradable scleral implants of indomethacin for prolonged ocular delivery

Abstract

The development of ethyl cellulose-based scleral implants of indomethacin, prepared by the casting method is described. The effect of ethyl cellulose concentration, drug loading and plasticizer concentration on the in vitro drug release characteristics were evaluated. The release of indomethacin from the prepared implants followed matrix diffusion kinetics and seemed to be dependent upon ethyl cellulose concentration, as well as the type and concentration of the plasticizer used. The swelling and moisture absorption/loss capacities of the implants correlated well with the in vitro release data.