Visible light-driven, persulfate-mediated dual C-H sulfenylation of imidazopyridines using thiocyanate salt

Abstract

We present a visible light-mediated dual C-H sulfenylation of imidazopyridines using thiocyanate salt as a sulfur source. This method achieves regioselective thiocyanation of imidazopyridines, which are subsequently converted to bis(imidazopyridine)disulfanes upon base treatment. The disulfides are further transformed into thioethers via nucleophilic attack of indoles, azaindole, benzothiazole, and additional imidazopyridines. The antioxidant properties of selected imidazopyridine derivatives were assessed using the DPPH assay, demonstrating notable potential for therapeutic applications. © 2024 The Royal Society of Chemistry.