Iontophoretic delivery of propranolol hydrochloride through human epidermis

Abstract

The passive and iontophoretic transport of propranolol hydrochloride (PHCl) has been studied through human epidermis by varying the pH of the donor solution and the current density. The steadystate flux during passive transport of PHCl was maximal at pH 11 and minimal at pH 7.4. The transport was enhanced during iontophoresis in comparison to the passive diffusion at all pHs. The cathodal iontophoretic flux was greater than anodal and was maximal at pH 11. The flux was also found to be proportional to the current density. One of the most important applications of this study is the possibility of enhancing and controlling the transdermal delivery of PHCl by iontophoresis. © 1992.