Transdermal delivery of indomethacin: I. Release profile of drug from polymeric patches

Abstract

Several polymeric patches of matrix type were prepared and evaluated for in-vitro release of indomethacin in order to select a suitable system for transdermal delivery. The solution casting technique employing both glass and mercury substrate was used for the preparation of patches. Keshary-Chien type diffusion cell was used for in-vitro release studies. The PVA-PVP patches (containing 2.5, 5 and 10% of drug) released 100% drug within the 24 hrs period of study. Eudragit RL100-PVP (in 8:2 ratio) with PEG 400 as plasticizer yielded smooth and flexible patches with good drug release profiles. The release of drug from many of the Eudragit based patches followed the diffusion controlled Higuchi Model. In conclusion, the combinations of PVA-PVP and Eudragit RL100-PVP matrices may potentially be developed as a transdermal therapeutic system.