Pd@TTF Tailored Nanostructured Platform: Voltammetric Estimation of Ceftazidime

Abstract

Herein, we report the synthesis of tetrathiafulvalene stabilized palladium nanocomposite (Pd@TTF) through one-step simple chemical route without using any external reducing agent. Prepared Pd@TTF was further used for the electrochemical determination of ceftazidime (CFZ). A possible interaction mechanism has been proposed for the formation of palladium NPs sandwiched between TTF radical cations (Pd@TTF). As-prepared Pd@TTF are characterized by using various techniques to investigate its structural, optical, and electrochemical properties The interaction of drug molecules with Pd@TTF is utilized in sensing of the drug using voltammetric techniques. The limit of detection (LOD) of CFZ is achieved up to 0.5 μM. The Pd@TTF modified sensor probe is successfully used for the determination of CFZ in the commercially available CFZ injection. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim