Determination of the Anti-HIV Drug Nevirapine Using Electroactive 2D Material Pd@rGO Decorated with MoS2 Quantum Dots

Abstract

Herein we report the detection of an anti-HIV drug Nevirapine (NVP) through a sensitive electrochemical method using efficient electro-active 2D materials; Palladium nanoparticles supported reduced graphene oxide (rGO), i.e., Pd@rGO, MoS2 quantum dots (QDs) and Pd@rGO decorated with MoS2 QDs modified electrodes. We have shown an interaction between Pd@rGO and MoS2 QDs in the composite based on FT-IR and UV-Vis. absorption studies. The interaction between Pd@rGO and MoS2 QDs in designed material leads to highly efficient electro-activity that is actually responsible for the broad spectrum quantification of frequently used anti-HIV drug Nevirapine. The electrochemical oxidation behaviour of NVP is studied using cyclic voltammetry (CV) over bare glassy carbon electrode and modified electrodes with alone Pd@rGO and MoS2 QDs and finally over designed material Pd@rGO/ MoS2 QDs. The excellent catalytic effect is observed over designed material as evident from oxidation at relatively lower potential of 0.65 V vs. Ag/AgCl and large peak current in comparison with others. Pd@rGO/ MoS2 QDs modified electrode exhibits a linear increase in oxidation peak current with an increase in NVP concentration in the range of 0.1 – 80 μM with limit of detection (LOD) of 50 nM at signal-to-noise ratio (S/N): 3. The developed sensing platform shows excellent stability and sensitivity to make it suitable for the determination of NVP in the complex system. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim