Effect of some metallic therapeutic ions on in vitro, physicomechanical and in vivo performances in 1393 and 1393B3 glass derived scaffolds

Abstract

This thesis reports the preparation of some metallic therapeutic ions (Copper, Zinc, and Strontium) incorporated 1393 or 1393B3 glass based scaffolds and their characterization through in vitro and in vivo investigations. The preparation of 1393 glass and their metallic ions derived scaffolds involve melting of proportionate amount of AR (analytical reagent) grade reagent followed by foam replication (melt-route) or stepwise hydrolysis and polycondensation of the precursors to prepare gels, and impregnation (gels) into PU foams (sol-gel route). The characterizations involve in vitro bioactivity and cytocompatibility, osteogenesis, mechanochemical performances and in vivo evaluations.