Potassium Persulfate-Glucose Mediated Synthesis of (3)-S-Arylthioindoles from Indole and Thiophenols in Water

Abstract

An efficient and eco-friendly method has been developed for the preparation of functionalized 3-(S)-arylthioindoles in good to excellent yields from indoles and aryl thiols in water. The coupling reaction was prompted by K2S2O8 in the presence of glucose at room temperature. Broad substrate scope, functional group tolerance, room temperature reactions and metal-free conditions are the salient features of the developed methodology. © 2023 Wiley-VCH GmbH.