Copper-promoted dehydrogenative cross-coupling reaction of dialkyl phosphites with sulfoximines

Abstract

An efficient method for the dehydrogenative cross-coupling of dialkyl phosphites with sulfoximines is demonstrated in the presence of copper(ii) acetate and triethylamine. A library of sulfoximines including aryl, heteroaryl and alkyl sulfoximines underwent coupling reaction smoothly and gave the desired sulfoximine derived phosphoramidates in good to excellent yields. © the Partner Organisations 2019.