Efficient Pd-catalysed Synthesis of 3-Amino-4-indolylmaleimides and 3-Amido-4-indolylmaleimides

Abstract

The Buchwald–Hartwig cross-coupling reaction of 3-bromo-4-indolylmaleimide with various anilines, aminopyridines and amides is described. A wide variety of 3-amino-4-indolylmaleimides and 3-amido-4-indolylmaleimides was prepared in good to excellent yields. We envisage that our protocol to access 3-(amino/amido)-4-indolylmaleimides will find use towards constituting new potentially biologically active compounds. © 2024 Wiley-VCH GmbH.