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A Bacteriophage Microgel Effectively Treats the Multidrug-Resistant Acinetobacter baumannii Bacterial Infections in Burn Wounds

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dc.contributor.authorDehari, Deepa
dc.contributor.authorChaudhuri, Aiswarya
dc.contributor.authorKumar, Dulla Naveen
dc.contributor.authorPatil, Rohit
dc.contributor.authorGangwar, Mayank
dc.contributor.authorRastogi, Sonam
dc.contributor.authorKumar, Dinesh
dc.contributor.authorNath, Gopal
dc.contributor.authorAgrawal, Ashish Kumar
dc.date.accessioned2024-04-03T07:05:06Z
dc.date.available2024-04-03T07:05:06Z
dc.date.issued2023-06-29
dc.descriptionThis paper published with affiliation IIT (BHU), Varanasi in open access mode.en_US
dc.description.abstractMultidrug-resistant (MDR) Acinetobacter baumannii (A. baumannii) is one of the major pathogens present in burn wound infections. Biofilm formation makes it further challenging to treat with clinically available antibiotics. In the current work, we isolated the A. baumannii-specific bacteriophages (BPABΦ1), loaded into the chitosan microparticles followed by dispersion in gel, and evaluated therapeutic efficacy against MDR A. baumannii clinical strains. Isolated BPABΦ1 were found to belong to the Corticoviridae family, with burst size 102.12 ± 2.65 PFUs per infected host cell. The BPABΦ1 loaded chitosan microparticles were evaluated for quality attributes viz. size, PDI, surface morphology, in vitro release, etc. The developed formulation exhibited excellent antibiofilm eradication potential in vitro and effective wound healing after topical application.en_US
dc.description.sponsorshipDepartment of Microbiology Institute of Medical Science Virus Research and Development Laboratory Department of Science and Technology, Ministry of Science and Technology, India Banaras Hindu University Indian Institute of Technology Delhien_US
dc.identifier.issn14248247
dc.identifier.urihttps://idr-sdlib.iitbhu.ac.in/handle/123456789/3076
dc.language.isoenen_US
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)en_US
dc.relation.ispartofseriesPharmaceuticals;16
dc.subjectantimicrobial resistance;en_US
dc.subjectbacterial biofilm;en_US
dc.subjectbacteriophage;en_US
dc.subjectmultidrug resistance;en_US
dc.subjectwound infectionen_US
dc.subjectantiinfective agent;en_US
dc.subjectchitosan derivative;en_US
dc.titleA Bacteriophage Microgel Effectively Treats the Multidrug-Resistant Acinetobacter baumannii Bacterial Infections in Burn Woundsen_US
dc.typeArticleen_US

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