Arsenic and antimony toxicity in drinking water and their roles in the development of PKDL

Abstract

The contamination of drinking water with arsenic has evolved into a major global health crisis, affecting millions of people in various regions. This study aims to examine the impact of arsenic contamination on the development of post-kala-azar dermal leishmaniasis (PKDL), a cutaneous manifestation of visceral leishmaniasis. The prevalence of arsenic in drinking water is a significant threat to public health, particularly in regions where natural arsenic sources, such as groundwater, are prevalent. Long-term exposure to arsenic through contaminated drinking water has been linked to a variety of adverse health outcomes, including skin disorders, cancer, and neurological problems. However, the relationship between arsenic contamination and PKDL development remains poorly understood. This chapter takes a comprehensive approach to examining the potential correlation between arsenic exposure and the emergence of PKDL. A critical new understanding of the molecular mechanisms underlying the pathogenesis of PKDL in response to arsenic exposure will be gained as a result of this investigation. Additionally, this study will aid in developing preventative measures and interventions to mitigate the harm that arsenic contamination causes to human health. In conclusion, this study aims to close the knowledge gap regarding the association between arsenic-contaminated drinking water and the onset of PKDL. By illuminating arsenic's role in PKDL pathogenesis, this study will lay the groundwork for effective public health interventions to mitigate the effects of arsenic contamination on affected communities. © 2025 Veer Singh and Ashish Kumar. All rights reserved.