AC Magnetic Field Dependent Hyperthermia for Controlled Heating Near Therapeutic Temperature

Abstract

Trivalent Al3+-doped samples of magnetite (Alx Fe3-xO4, 0.01≤ x ≤1.0) were produced by wet chemical method. The X-ray diffraction studies confirmed the formation of a single-phase inverse spinel-type structure. Particles having spherical morphology and size range lying between 4 and 25 nm were observed during transmission electron microscopic investigation. Magnetic measurement displayed increase in saturation magnetization with a maximum value of 62 A\cdot m2/kg for x =0.1, and thereafter, it started decreasing with increased concentration of Al. The temperature during magnetic hyperthermia got stabilized near therapeutic range (315 K) for the samples such as x =0.01, 0.5, 0.7, and 1.0 at various external alternating current magnetic fields. © 1965-2012 IEEE.