Nanodelivery of cerebrolysin induces profound neuroprotection in heat stroke following chronic hypertension in combination with Si02 and carbon nanoparticles induced exacerbation of brain damage

Abstract

Military personals are often exposed to combat stress induced hypertension in an environment rich in various nanoparticles (NPs) emanating from different sources e.g., gun powder explosion or blast injuries. Furthermore, combat or peacekeeping activity in the Middle East region also exposes them to high environmental heat and silica dust. Thus, it is quite likely that all these combinations of hypertension, silica dust (Si02 NPs) and carbon NPs following missile explosion or blast injuries in desert high heat lead to exacerbation of brain damage following heat stroke. This suggests that hypertension and/or NPs exposure in high environmental heat is dangerous for our soldiers as a combination of these factors may induce brain dysfunction and damage along with functional disturbances. In this innovation we have shown that a combination of hypertension, Si02 NPs and carbon nanoparticles (CNPs) at hot environment aggravates brain damage. In this complex situations Ti02-nanowired delivery of multimodal drugs e.g., cerebrolysin is needed to contain neuronal damage and restoring the functional disturbances effectively. Copyright 2015 by TechConnect. All rights reserved.