Antibacterial and antitubercular activities of some diphenyl hydrazones and semicarbazones

Abstract

Condensation of phenoxy or 4-bromophenoxy acetic acid hydrazide and substituted aryl semicarbazides with appropriate carbonyl compounds yield corresponding hydrazones and semicarbazones, respectively. The chemical structure of the synthesized compounds has been confirmed by UV, IR and 'H NMR spectral data. All the compounds have been investigated for their antibacterial activity against ten pathogenic strains and antitubercular activity against Mycobacterium tuberculosis H37 Rv. Compound 4f, Acetic acid, phenoxy-,[l-(4-chlorophenyl) ethylidene] hydrazide has been found to exhibit 80% inhibition in the preliminary antitubercular screening (MIC >6.25 |ig/mL). © 2010 The Council of Scientific and Industrial Research.