DESIGN, SYNTHESIS, PHARMACOLOGICAL EVALUATION AND MOLECULAR MODELLING STUDY OF QUINAZOLIN–4(3H)–ONES AS POTENTIAL ANTICONVULSANT AGENTS

Abstract

An epileptic seizure is a transient occurrence of symptoms due to abnormal excessive or synchronous neuronal activity in the brain. According to the WHO, epilepsy affects around 50 million people worldwide and majority of the epileptic patient are found in the developing regions. It is the most common brain disorder worldwide with no age, racial, social class, national or geographic boundaries. Understanding the causes of epilepsy is essential both for the management and discovery of target–specific anticonvulsant drugs. Anticonvulsant drug therapy is the primary line of treatment to control epileptic seizure.