Mechanochemical and in vitro cytocompatibility evaluation of zirconia modified silver substituted1393 bioactive glasses

Abstract

Zirconia and silver oxide substituted 1393 bioactive glasses (1393Zr and 1393Zr-1Ag) wereprepared by sol-gel technique and sintered at 900-1100°C. ZrO2incorporation into theglass was on the sole purpose of mechanical performance augmentation, while Ag2O beingantibacterial, their incorporation on microbial efficacy, in vitro bioactivity and cytocompat-ibility were assessed. The Ag2O incorporated glass showed minimal effect on bioactivity ofthe parent glass. Both the cytocompatibility (U2-OS cells using MTT assay) and antibacterialefficacy (by using Bacillus subtilis; and Escherichia coli) were found significantly improved in sil-ver doped glass than the undoped one. Excellent mechanical performance was also observedin 1393Zr-1Ag compared to the both pure 1393 glass and 1393Zr. Thus, Ag2O incorporationinto 1393Zr not only introduced the bactericidal efficacy, but also enhanced the mechanicalproperties of the glass, while leaving bioactivity unharmed. Thus the Ag2O incorporated1393Zr seems a potential biomaterial for bone tissue engineering application. © 2020 SECV. Published by Elsevier España, S.L.U.