Analgesic activity and hypnosis potentiation effect of (±)-3-menthone semicarbazone and thiosemicarbazone derivatives

Abstract

A series of (±)-3-menthone semicarbazone and thiosemi-carbazone derivatives (3a-j) were synthesised and screened for analgesic and hypnotic activities. Almost all compounds exhibited analgesic activity and (±)-3-menthone semicarbazone (3a) was found to be the most potent. In the hypnotic test, compound 3c showed a pentobarbitone-like effect.