Hypoglycemic activity of Withania coagulans Dunal in streptozotocin induced diabetic rats

Abstract

Administration of aqueous extract of fruits of Withania coagulans Dunal significantly lowered the blood sugar, serum cholesterol, serum LPO, and hepatic LPO levels at the highest concentration of 1 g/kg; po in streptozotocin induced diabetic rats. In normal rats as well the blood sugar levels were significantly decreased following treatment with the above drug. Withania coagulans also exhibited free radical scavenging activity in an in vitro system using DPPH. © 2004 Elsevier Ireland Ltd. All rights reserved.