A Review on Biodegradable Polymeric Materials for Bone Tissue Engineering (BTE) Applications

Abstract

Bone is dynamic tissues have structural and functional complexity with varying mechanical strength as of skeletal, craniofacial maxillary position. Despite surgery, allograft, advanced therapy, treatment of critical defects, deformities and functional restoration of bone are still challenging. BTE provides the hope, which could resolve the surgical challenges by developing the artificial functionalized bone. Use of biodegradable polymers in BTE provides variable required mechanical properties, porosity, and surface microenvironment for cellular adhesion, osteoblast proliferation and differentiation. Non-antigenic, immunomodulatory, vascularization, cytocompatibility, adjustable degradation kinetics, hydrolytic/enzymatic degradation and release of biocompatible metabolites are the main characteristics that enable biodegradable polymers for making 3D-scaffold for BTE. In the above line, this article illustrates the different biodegradable polymers that useful for the bone microenvironment and for the repair bone tissues. © 2022 Elsevier Inc. All rights reserved.