Bioinformatics in skin cancer: A system biology approach to understanding the molecular mechanisms and it’s regulations

Abstract

In last few years, average life expectancy of humans has increased globally. Exposure to hazardous chemicals, ultraviolet (UV) radiation and other carcinogens has also increased the cancer burden in humans. Skin cancer is mainly associated with the DNA damage because of the prolonged exposure to UV radiation. Several structural changes, mutations and amplifications of oncogenes have been reported in skin cancer. The continuous development of bioinformatics approaches, next-generation sequencing, proteomics, transcripts, and epigenetic analysis has increased the understanding of cancer progression and molecular mechanisms and to design appropriate drug for the diseases. In this chapter, we have discussed the importance of bioinformatics in understanding the molecular mechanisms of skin cancer progression, related signaling pathways, data analysis, and drug development. © Springer Nature Singapore Pte Ltd. 2019.