Biological activity of mannich bases

Abstract

Mannich reaction involves condensation of a carbonyl compound with formaldehyde and a secondary amine. It is a mild procedure for obtaining unsaturated ketones (usually -CO-C=CH2). Mannich bases derived from chalcones and 2-dimethyl amino ethyl benzo suberone methiodide have shown promise as anticancer agents, 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-[N 4(5′-chloro-3′-thiosemicarbazono-isatin-1-yl) methyl)-N-piperazinyl]-3-quinoline carboxylic acid had been found to be more active than norfloxacin.