Development and characterization of buccoadhesive patches of pentazocine

Abstract

Buccoadhesive patches for the delivery of pentazocine to the buccal mucosa were prepared using polymers like CMC, HPMC K4M and combination of Carbopol 974P and PVA. Patches were evaluated for physical characteristics, in vitro bioadhesion strength, swelling rate of polymers and in vitro drug release characteristics in pH 6.6 phosphate buffer. The formulations showed significant bioadhesive properties and exhibited prolonged and controlled drug release profiles. The type of polymer and the patch significantly affected the rate and extent of drug release.