An Efficient Metal-Free Method for the Denitrosation of Aryl N-Nitrosamines at Room Temperature

Abstract

A simple and practical method for the denitrosation of aryl N-nitrosamines to secondary amines is reported under metal-free conditions using iodine and triethylsilane. Several reduction-susceptible functional groups such as alkene, alkyne, nitrile, nitro, aldehyde, ketone and ester were found to be very stable during the denitrosation, which is remarkable. Broad substrate scope, room temperature reactions and excellent yields are the additional features of the current methodology. (Figure presented.). © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim