An Efficient, Green, and Solvent-free Multi-component Synthesis of Benzimidazolo/Benzothiazolo Quinazolinone Derivatives Using Sc (OTf)3 Catalyst Under Controlled Microwave Irradiation

Abstract

An efficient, fast, and green synthesis of benzimidazolo/benzothiazolo quinazolinone derivatives has been developed under solvent-free conditions by the reaction of 2-aminobenzimidazole/2-aminobenzothiazole, aromatic aldehydes, and 1,3-diketones. This method extended the application of microwave irradiation and scandium triflate combination and also tenders a lot of benefits such as excellent product yields, shorter reaction time, easy isolation of products, and environmentally benign reaction conditions. © 2018 Wiley Periodicals, Inc.