Nanomaterial Functionalization Strategies in Bio-Interface Development for Modern Diagnostic Devices

Abstract

Nano-biotechnology has paved a way towards the design and development of new diagnostic strategies and nano-medicine. The scope of recent nano-sensors for profound and selective sensing of numerous biomarkers is significant in different areas comprising health, environment, and food industries. To develop such systems often requires several functionalization steps for numerous nano-bio-conjugates, which are eventually applied for these biomedical applications. Moreover, to utilize the applications of nanomaterials present in the nano-bio-conjugates, there is a need to study the interactions happening at the nano-bio-interface. In view of such fresh growths in nanotechnology, the present book chapter has been framed underlining the part of nanomaterials in surface designing, biomolecular conjugations, and interactions happening at nan-bio-interface. In the chapter, the challenges towards working at the nano dimension and requirement of functionalization for biosensor development are addressed. Stress has been given on deciphering the classical strategies occurring at the nano-bio-interface, which are usually utilized for surface engineering and material functionalization. To put a better insight for the readers of interdisciplinary areas, an extended table has been incorporated, indicating the functionalization strategies and their uses. © Springer Nature Singapore Pte Ltd. 2020.