Potassium Persulfate-Promoted N-Nitrosation of Secondary and Tertiary Amines with Nitromethane under Mild Conditions

Abstract

A simple and efficient route for the N-nitrosation of various secondary amines with nitromethane is described in the presence of potassium persulfate and DBU. Under optimized condition, tertiary amines underwent a dealkylative N-nitrosation with good yields. Inexpensive reagents, broad substrate scope and efficient conversion make the current protocol more attractive in organic synthesis. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim