Solvent-free microwave-assisted synthesis of 1H-indole-2, 3-dione derivatives

Abstract

(Chemical Equation Presented) Microwave-assisted synthesis has been found to increase both reaction rates and yields via more efficient heating compared with standard thermal conduction. Dry reaction of isatins with thiosemicarbazide and their thiosemicarbazone with secondary amine on acid-washed K10 in microwave oven afforded isatin-3-thiosemicarbazones and N-Mannich bases in reasonably good yield. The chemical structures were confirmed by means of 1H NMR, IR spectral data, and elemental analysis. © 2009 HeteroCorporation.