RNA-Based Vaccines for Infectious Disease

Abstract

Infectious disease is mainly caused by bacteria and viruses. Over time, the world has suffered from various bacterial and viral-born endemics or pandemics such as Ebola, SARS-CoV-2, and influenza. Hence, the development and advancement of a rapid, scalable, and cost-effective platform is essential for supplying on-demand vaccines for prophylactic and therapeutic use. Recently, the vaccine development platform is shifting toward self-amplifying mRNA (saRNA) technology for providing a quicker response against emerging infectious outbreaks. In this chapter we have focused on a brief introduction of vaccinology history, the benefits of saRNA over mRNA, and the immune response provoked by the saRNA vaccine. Additionally, we have addressed preparation, purification, delivery, and pharmacokinetic aspects of the saRNA vaccine. We have limited our discussion to the saRNA vaccine for infectious disease, clinical translation, and future prospects. © 2022 selection and editorial matter, Yashwant V. Pathak; individual chapters, the contributors.