Hepatoprotective effect of crude extract and isolated lignans of Justicia simplex against CCl4-induced hepatotoxicity

Abstract

The lignan-rich petroleum ether extract and the isolated lignans, simplexolin and sesamolin, of Justicia simplex D. Don (Acanthaceae) were tested for protective effect on CCl4-induced hepatotoxicity in rats. The induced CCl4 toxicity elevated the levels of marker enzymes alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and stimulated lipid peroxidation along with decrease in triglycerides and glutathione content. The pretreatment with the extract and the isolated lignans at the dose of 100 mg/kg p.o. and 10 mg/kg p.o., respectively, normalized these toxic levels. The effect of the isolated lignans was comparable with the standard (Nirocil). This showed the hepatoprotective effect of petroleum other extract and lignans of J. simplex. © 2007 Informa Healthcare.