Bioavailability studies on fast release formulations of indomethacin

Abstract

Indomethacin-nicotinamide solid dispersions were prepared by fusion method. Drug-carrier interaction in the liquid and solid states were studied using phase solubility data and differential scanning colorimetry (DSC). DSC revealed the formation of an eutectic mixture of indomethacin and nicotinamide. Tablets and capsules, formulated from the solid dispersions showed significantly better dissolution and enhanced absorption rate in human volunteers, compared to commercial capsule of indomethacin.