PROTECTIVE ROLE OF SITAGLIPTIN IN THE TREATMENT OF OBESITY AND ASSOCIATED METABOLIC COMPLICATIONS IN ANIMAL MODEL OF HIGH-FAT DIET-INDUCED OBESITY

Abstract

Obesity, a nutritional disorder, has become one of the major challenges for public health in the 21st century. The serious adverse consequences of obesity are insulin resistance, type-2 diabetes mellitus, non-alcoholic fatty liver disease, cardiovascular complications, osteoarthritis, depression, and also cancer. The fundamental cause of obesity involves an imbalance in the energy homeostasis in the body, basically due to the increased consumption and decreased expenditure of calories, eventually increasing the adiposity. According to the World Health Organization estimates, the prevalence of obesity has tripled in just forty-one years worldwide across all the age groups, reaching pandemic levels.