Synthesis of biocompatible TiO2 nanodots: Glancing angle deposition technique

Abstract

Titanium dioxide nanodots have widely been explored in biomedical application due to its unique physiochemical properties. In this study, TiO2 nanodots arrays were synthesized on p-type Si substrate by the glancing angle deposition technique. The transmission electron microscopy image shows that the particle size is between 1-15 nm. X-ray diffraction (XRD) and selected area electron diffraction (SEAD) analysis shows the polycrystalline nature of the nanodots, which is dominated by rutile phase. Optical absorption and transmission were recorded in UV region. The maximum photoluminescence emission intensity has been observed at 3.28 eV (∼377 nm) from TiO2 NDs. Biocompatibility of TiO2 NDs against blood platelets and erythrocytes (RBCs) was studied respectively by MTT assay and in vitro hemolysis assay, elucidating the excellent hemocompatibility of TiO2 nanodots. So, the chemical stability, and biocompatibility of TiO2 Nanodots makes this nanomaterial an ideal for application in bio-medical field. Copyright © 2016 American Scientific Publishers All rights reserved.