Solid-state fermentation strategy for microbial metabolites production: An overview

Abstract

Until now a number of studies have been made on microbial metabolites production at the industrial scale. Among these, solid-state fermentation (SSF) is known as one of the potential processes for metabolites production. Though plenty of information exists for SSF technology, the lack of a basic concept to improve SSF process is still the major difficulty. This is because of the gap in the proper standardization and analysis of existing factors of SSF which may contribute significantly to improve the SSF process for efficient metabolites production. Several research works have been explored regarding the production of metabolites and spores through the SSF process using different types of substrates. Besides improving from the bench scale, an engineering factor that may contribute toward the economy and enhancement in SSF process should also be covered along with crucial factors of SSF such as substrate and physicochemical parameters. SSF has many biotechnological advantages which may be enhance/improved by adopting suitable strategies. Therefore the objective of the present chapter is to explore sustainable strategies within the existing parameters of SSF for an improvement in metabolites production at the industrial scale. This chapter discusses various significant parameters which may influence SSF significantly, along with the presently feasible approaches to improve them further. Additionally, an engineering aspect for improvement for a pilot-scale study is also presented and the enhancement of microbial metabolites production at large scale is also discussed. © 2018 Elsevier B.V. All rights reserved.