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Axisymmetric bis-tridentate Ir(iii) photoredox catalysts for anticancer phototherapy under hypoxia

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dc.contributor.authorWei, Li
dc.contributor.authorKushwaha, Rajesh
dc.contributor.authorDao, Anyi
dc.contributor.authorFan, Zhongxian
dc.contributor.authorBanerjee, Samya
dc.contributor.authorHuang, Huaiyi
dc.date.accessioned2024-03-14T11:29:46Z
dc.date.available2024-03-14T11:29:46Z
dc.date.issued2023-02-14
dc.descriptionThis paper published with affiliation IIT (BHU), Varanasi in open access mode.en_US
dc.description.abstractA novel axisymmetric bis-tridentate Ir(iii) photocatalyst (Ir3) with synergetic type I/II photosensitization and photocatalytic activity was reported. Ir3 exhibited high photocytotoxicity toward drug-resistant cancer cells under normoxia and hypoxia. The photoactivated anticancer mechanism of Ir3 were investigated in detail. Overall, this new photo-redox catalyst can overcome hypoxia and drug resistance-related problems in clinical anticancer therapy.en_US
dc.description.sponsorshipWe appreciate the financial support from the National Natural Science Foundation of China (NSFC 22277153, 22007104), Guangdong Basic and Applied Basic Research Foundation (2021B1515020050), the Fundamental Research Funds for the Central Universities (22lgqb37), the Science, Technology and Innovation Commission of Shenzhen Municipality (JCYJ20190807152616996), and SERB (SRG/2022/000030), the Government of India. R. Kushwaha thanks the Ministry of Education, the Government of India for the Prime Minister’s Research Fellowship.en_US
dc.identifier.issn13597345
dc.identifier.urihttp://localhost:8080/xmlui/handle/123456789/2988
dc.identifier.urihttps://idr-sdlib.iitbhu.ac.in/handle/123456789/2988
dc.language.isoenen_US
dc.publisherRoyal Society of Chemistryen_US
dc.relation.ispartofseriesChemical Communications;59
dc.subjectAntineoplastic Agentsen_US
dc.subjectCatalysisen_US
dc.subjectHumansen_US
dc.subjectHypoxiaen_US
dc.subjectPhototherapyen_US
dc.titleAxisymmetric bis-tridentate Ir(iii) photoredox catalysts for anticancer phototherapy under hypoxiaen_US
dc.typeArticleen_US

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