Metal-Free Synthesis of S -Aryl Dithiocarbamates: A Direct Approach from Anilines and Secondary Amines in the Presence of tert -Butyl Nitrite

Abstract

A simple and efficient method was developed for the preparation of S -aryl dithiocarbamates from anilines, carbon disulfide, and amines in acetonitrile-water. The reactions proceeded at room temperature in the absence of catalysts, and the desired products were obtained in good to excellent yields. Simple operations, easy access to reactants, catalyst-free conditions, and high product yields are key benefits of this method. © 2025. Thieme. All rights reserved.