'Plate-like-coral' polymer particles with dendritic structure and porous channels: Effective delivery of anti-cancer drugs

Abstract

'Plate-like-coral' shaped polymer capsule (PC-PLCDB) with dendritic network structure and porous channels has been synthesized and used for therapeutic purposes. First di-block copolymer [(PEG)-b-(L-AspA)n] has been synthesized from PEG (polyethylene glycol) and aspartic acid (AspA). Then the biocompatible PC-PLCDB has been achieved by homogeneous mixing of [(PEG)-b-(L-AspA)n] and poly-N-isopropyl acrylamide (PNIPAM) followed by reprecipitation. Only H-bonding is responsible for the foundation of self-assembly of the polymer chains and to form PC-PLCDB. A huge extent of loading anticancer drug, for example, doxorubicin (DOX) in PC-PLCDB is possible. in vitro study has been performed to check the therapeutic efficacy of PC-PLCAD-DOX formulation on chronic myeloid leukemia cells (K562). The IC50 has been calculated to be 0.405 (±0.014) ng μg−1 of the formulation. PC-PLCAD-DOX inhibits 80% of the cancer cell only by 1.0 μg mL−1 of the formulation. This study reveals that the PC-PLCAD could be a promising candidate for therapeutic applications. © 2020 Wiley Periodicals LLC.