DABCO Catalyzed Synthesis of β-Hydroxy Ketones Derived from α-Methyl Ketones and Ninhydrin under Microwave Irradiations

Abstract

Microwave induced an efficient, green and rapid protocol for the synthesis of 2-substituted-2-hydroxyindan-1,3-dione derivatives from the reaction of ninhydrin and ketone by using inexpensive 1,4-diazabicyclo[2.2.2]octane (DABCO) organocatalyst in water has been developed. Mild reaction conditions, shorter reaction time, metal-free approach, water as a green solvent, scalability and broad substrate scope are the salient features of this protocol. © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim