Functionalization Strategies for the Development of Nano-Bio-Conjugates in Contemporary Point-of-Care Analytical Devices

Abstract

Nanobiotechnology has enabled the path for novel diagnostic strategies and nanomedicine to be developed and tested. Potential biomarker detection by existing nanosensors is significant in a wide range of industries, including healthcare and environmental monitoring as well as the food industry. Developing such systems frequently necessitates several functionalization stages for a large number of nano-bio-conjugates, which are then used in biomedical applications. Researchers must also look at the interactions that occur at the nano-bio-interface in order to take advantage of the usage of nanomaterials found in nano-bio-conjugates. Surface design, biomolecular conjugations, and sensor-interface interactions have been highlighted in this book chapter due to recent breakthroughs in nanotechnology. The limitations of operating at the nanoscale and the need for functionalization in biosensor fabrication are discussed in this chapter. The importance of deciphering the classic methodologies utilized for surface engineering and material functionalization has been highlighted. An additional table has been included to give readers of interdisciplinary fields a better understanding of the functionalization procedures and their applications. © The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2023.